[{"data":1,"prerenderedAt":417},["ShallowReactive",2],{"about":3},{"id":4,"title":5,"body":6,"description":409,"extension":410,"meta":411,"navigation":412,"path":413,"seo":414,"stem":415,"__hash__":416},"pages\u002Fpages\u002Fabout.md","About · Reece Hart",{"type":7,"value":8,"toc":401},"minimark",[9,14,95,106,111,149,153,162,196,216,239,255,292,295,299,302,350,354,381],[10,11,13],"h1",{"id":12},"about-me","About Me",[15,16,17,18,22,23,26,27,34,35,40,41,44,45,34,50,55,56,44,59,64,65,70,71,74,75,78,79,82,83,86,87,90,91,94],"p",{},"I am a scientist and ",[19,20,21],"strong",{},"product-focused engineering leader"," with over two\ndecades of experience architecting, building, and operating reliable software\nsystems for research, healthcare, and business -- in ",[19,24,25],{},"large companies","\n(",[28,29,33],"a",{"href":30,"rel":31},"https:\u002F\u002Fibm.com\u002F",[32],"nofollow","IBM",", ",[28,36,39],{"href":37,"rel":38},"https:\u002F\u002Fgene.com\u002F",[32],"Genentech","), ",[19,42,43],{},"zero-to-one\nstartups"," (",[28,46,49],{"href":47,"rel":48},"https:\u002F\u002Finvitae.com\u002F",[32],"Invitae",[28,51,54],{"href":52,"rel":53},"https:\u002F\u002Fmyome.com\u002F",[32],"MyOme","), and\n",[19,57,58],{},"open source collaborations",[28,60,63],{"href":61,"rel":62},"https:\u002F\u002Fbiocommons.org\u002F",[32],"biocommons.org",",\n",[28,66,69],{"href":67,"rel":68},"https:\u002F\u002Fga4gh.org\u002F",[32],"GA4GH",").  I have been a ",[19,72,73],{},"CTO",", a ",[19,76,77],{},"founder and executive\ndirector"," of academic\u002Findustry collaboration, and I have ",[19,80,81],{},"primary and senior\nauthorship"," of international standards for representing biological sequence\nvariation.  I have direct experience in ",[19,84,85],{},"contract negotiation"," and\n",[19,88,89],{},"partnership management",".  I am ",[19,92,93],{},"currently available"," for full-time\nemployment or contracting in scientific software engineering or civic causes.  I\nthrive in startup environments where every day is an opportunity to create\nenduring value.",[15,96,97,98,101,102,105],{},"I have a knack for helping teams articulate mission and strategy messages while\nstaying focused on incremental delivery of tangible value.  I enjoy\ncollaborating with smart people to solve complex problems and ",[19,99,100],{},"leading teams\nthat create products that matter",".  I think strategically and have a bias\ntoward\naction, and am comfortable building scrappy solutions for quick answers and\nresilient systems for mission-critical operations.  As a startup veteran, ",[19,103,104],{},"I\nexpect to build value within constrained resources",".",[107,108,110],"h2",{"id":109},"education","Education",[15,112,113,114,119,120,125,126,131,132,34,137,142,143,148],{},"I earned a BA in molecular biology from ",[28,115,118],{"href":116,"rel":117},"https:\u002F\u002Fucsd.edu\u002F",[32],"UC San Diego"," and\nworked on early mapping of chromosome 11 for the nascent Human Genome Project at\nthe ",[28,121,124],{"href":122,"rel":123},"https:\u002F\u002Fsalk.edu\u002F",[32],"Salk Institute",".  I then completed a dual PhD\u002FMS in\nmolecular biophysics and computer science at Washington University in St. Louis,\nfollowed by post-doctoral work at the ",[28,127,130],{"href":128,"rel":129},"https:\u002F\u002Fresearch.ibm.com\u002Flabs\u002Fyorktown-heights",[32],"IBM Watson Research\nCenter",".  This education was\nenabled by public funding through the ",[28,133,136],{"href":134,"rel":135},"https:\u002F\u002Fnih.gov\u002F",[32],"National Institutes of\nHealth",[28,138,141],{"href":139,"rel":140},"https:\u002F\u002Fnsf.gov\u002F",[32],"the National Science Foundation",",\nand the ",[28,144,147],{"href":145,"rel":146},"https:\u002F\u002Fdoe.gov\u002F",[32],"Department of Energy",", for which I am very grateful.",[107,150,152],{"id":151},"professional-experience","Professional Experience",[15,154,155,156,161],{},"This section contains only my career highlights; see my ",[28,157,160],{"href":158,"rel":159},"https:\u002F\u002Ft.ly\u002Freece-cv",[32],"Curriculum Vitae\n(PDF)"," for a complete employment history.",[15,163,164,165,167,168,171,172,175,176,179,180,183,184,187,188,191,192,195],{},"As ",[19,166,73],{}," at ",[28,169,54],{"href":52,"rel":170},[32]," (2020-2025), I translated company\nmission and strategy into actionable roadmaps.  I ",[19,173,174],{},"built the engineering\nteam",", managed the initial clinical operations team that received our first ~50\nclinical samples, hired our first project managers, and oversaw compliance\nefforts as our ",[19,177,178],{},"first privacy and security officer",".  I was the ",[19,181,182],{},"system\narchitect"," of our system for clinical genetics test ordering, processing, and\ninterpretation, and I implemented significant portions of early versions of it.\nI contributed to ",[19,185,186],{},"product vision"," and ",[19,189,190],{},"managed several partner\nrelationships"," as the company evolved.  I am particularly proud of the team\nthat we ",[19,193,194],{},"hired while we designed and built a nimble, solid, and secure\nplatform"," that adapted as the company sought product-market fit while still\nproviding a foundation for high volume, CAP\u002FCLIA\u002FHIPAA compliance, and extremely\nhigh marks for penetration testing and architectural reviews by third parties.",[15,197,198,199,203,204,207,208,211,212,215],{},"At ",[28,200,49],{"href":201,"rel":202},"https:\u002F\u002Fwww.invitae.com\u002F",[32]," (2010-2017), I began as an unpaid\nscientific consultant and reference to venture capital firms during Invitae's\nSeries A fundraising.  I was among the initial team of tremendously talented and\nfocused individuals who developed the laboratory methods and systems that proved\nthe clinical and financial effectiveness of next generation sequencing for\nclinical genetics.  We delivered reports to over six million patients and their\nclinicians before the company was acquired by LabCorp.  I architected and\n",[19,205,206],{},"directed the implementation of our first interpretation pipeline",", and I\ndesigned of our second gene panel.  I also held primary responsibility for our\nAWS cloud environment.  I led the team that built our ",[19,209,210],{},"clinical-grade system\nthat enabled genome interpretation",".  I was actively involved in most of our\nearly hiring within and outside engineering as the company ",[19,213,214],{},"scaled to roughly\n750 employees"," during my tenure.  It was a privilege to work with this team and\nsee Invitae grow from seed stage to a successful company with profound clinical\nimpact.",[15,217,198,218,222,223,226,227,230,231,234,235,238],{},[28,219,39],{"href":220,"rel":221},"https:\u002F\u002Fwww.gene.com\u002F",[32]," (2001-2009), I started as an individual\ncontributor scientist, built a small team working on protein structure\nprediction, and eventually managed computing for Research.  My research program\nfocused on using protein structure prediction to ",[19,224,225],{},"discover novel therapeutic\ntargets"," in the (then) draft human genome.  This work led to the development of\nUnison, the protein annotation system that was used by research, development,\nand legal teams for over a decade to discover and analyze protein sequences.\nUnison ",[19,228,229],{},"integrated and continuously updated, indexed, and tracked provenance","\nof feature predictions from over 60 sources and methods across all known human\nand non-human proteins and it contributed to numerous drug target development\nprograms.  I was ",[19,232,233],{},"promoted to manage Research Computing"," and became\nresponsible for the architecture, budget, operations, and coordination of\ncomputing services that served ~1300 staff in Genentech Research.  In that role,\nI routinely met with directors of computing-intensive departments to plan\nspending (combined capital + operational budget of $30-35M) and to coordinate\nthe work of the more than 20 IT and application personnel.  I ",[19,236,237],{},"negotiated\nsignificant contracts"," for software and computing services used by Research.",[15,240,241,242,245,246,250,251,254],{},"I am the ",[19,243,244],{},"founder and executive director"," of\n",[28,247,63],{"href":248,"rel":249},"http:\u002F\u002Fbiocommons.org",[32]," where I coordinate the efforts of an\ninternational team of academic and industry professionals.  For over ten years,\nthis community has built and maintained pre-competitive open source resources\nfor genome interpretation that are ",[19,252,253],{},"trusted by clinical genetics companies and\nacademic researchers around the globe",".  The biocommons steering committee\nincludes representatives from academia and industry.",[15,256,257,258,261,262,267,268,271,272,276,277,282,283,286,287,105],{},"I have joined and helped build open and academic efforts to promote standards.  I\nam the ",[19,259,260],{},"primary author"," of the most recent update to the ",[28,263,266],{"href":264,"rel":265},"https:\u002F\u002Fdoi.org\u002F10.1186\u002Fs13073-024-01421-5",[32],"HGVS\nNomenclature",", an\ninternationally-recognized standard for the description of DNA, RNA, and protein\nsequence variants.  I ",[19,269,270],{},"founded and chaired"," the Variation Representation effort\nat the ",[28,273,275],{"href":67,"rel":274},[32],"Alliance for Genomics and Health",", and I am the\nprimary architect of the ",[28,278,281],{"href":279,"rel":280},"https:\u002F\u002Fvrs.ga4gh.org\u002F",[32],"Variation Representation\nSpecification"," and the ",[19,284,285],{},"senior author"," of the\n",[28,288,291],{"href":289,"rel":290},"https:\u002F\u002Fdoi.org\u002F10.1016\u002Fj.xgen.2021.100027",[32],"resulting manuscript",[15,293,294],{},"I have expertise with Linux, Python, PostgreSQL, AWS, GCP, CI\u002FCD, data\nengineering, security, and devops.  I am a practiced, thoughtful, and skeptical\nuser of AI throughout product development, including brainstorming, competitive\nanalyses, feature prioritization, product roadmapping, system architecture,\nimplementation planning, and frontend and backend implementation.",[107,296,298],{"id":297},"civic-engagement","Civic Engagement",[15,300,301],{},"Over the last decade, I have become increasingly determined to use my time,\nskills, and experience to improve political representation in the United\nStates.  During a year-long sabbatical (Sep 2025-Aug 2026), I have devoted\nmuch of this time to volunteering for and contracting with organizations\nthat seek to improve political discourse and engagement.",[15,303,304,305,310,311,316,317,322,323,328,329,34,334,64,339,344,345,105],{},"In 2017, I began volunteering with ",[28,306,309],{"href":307,"rel":308},"https:\u002F\u002Fstateswin.org\u002F",[32],"States Win"," (then\nknown as Sister District), including extensive canvassing in Arizona,\nco-organizing the San Francisco chapter's canvassing effort in 2019, and leading\na Virginia canvassing delegation that led to the VA trifecta.  In 2020, I was a\ncore member of the small, passionate, and all-volunteer team that built\n",[28,312,315],{"href":313,"rel":314},"http:\u002F\u002Flandslide2020.org",[32],"landslide2020.org",", a relational organizing platform\nto promote accountability among friends.  In 2026, I helped modernize\n",[28,318,321],{"href":319,"rel":320},"https:\u002F\u002Findivisiblesf.org",[32],"Indivisible SF's website",".  I also built ",[28,324,327],{"href":325,"rel":326},"http:\u002F\u002Fnokingscountdown.org\u002F",[32],"No Kings\nCountdown"," to motivate people leading up to No\nKings 3 on March 28, 2026.  I am currently working on Civic Center, a personal\npassion project to help people identify their political and social values, and\nto use this awareness to increase their civic engagement in elections,\nrepresentative relationships, and other forms of political action.  In the\ncourse of building these tools, I have used APIs and services from Alloy,\n",[28,330,333],{"href":331,"rel":332},"https:\u002F\u002Fballotpedia.org",[32],"Ballotpedia",[28,335,338],{"href":336,"rel":337},"https:\u002F\u002Fdevelopers.google.com\u002Fcivic-information",[32],"Google's Civic\nInformation",[28,340,343],{"href":341,"rel":342},"https:\u002F\u002Fcongress.gov",[32],"Congress.gov",", and ",[28,346,349],{"href":347,"rel":348},"https:\u002F\u002Fvote.org\u002F",[32],"Vote.org",[107,351,353],{"id":352},"personal-life","Personal Life",[15,355,356,357,362,363,368,369,374,375,380],{},"I live in San Francisco with my wife, ",[28,358,361],{"href":359,"rel":360},"https:\u002F\u002Fwww.linkedin.com\u002Fin\u002Fhanna-hart\u002F",[32],"Hanna\nHart",", where we raised three (now\nadult) children.  I play\n",[28,364,367],{"href":365,"rel":366},"https:\u002F\u002Fen.wikipedia.org\u002Fwiki\u002FUltimate_frisbee",[32],"ultimate"," regularly in pickup,\nleagues, and club teams.  I have coached youth ultimate through ",[28,370,373],{"href":371,"rel":372},"https:\u002F\u002Fwww.ultimate-impact.org\u002F",[32],"Ultimate\nImpact"," for eight years.  I sail regularly on\nSan Francisco Bay, including lighthearted racing through the ",[28,376,379],{"href":377,"rel":378},"https:\u002F\u002Fsouthbeachyachtclub.org\u002F",[32],"South Beach Yacht\nClub",".  We enjoy traveling, scuba diving, good\nfood, dinner parties, and of course our dogs, Chewie and Wilbur.",[382,383,386],"div",{"className":384},[385],"photo-row",[15,387,388,393,397],{},[389,390],"img",{"alt":391,"src":392},"Reece sailing on Fogdog","\u002Fimages\u002Fskipper.webp",[389,394],{"alt":395,"src":396},"Thirst'n'Howl","\u002Fimages\u002Ftnh.webp",[389,398],{"alt":399,"src":400},"The dogs, Chewie and Wilbur","\u002Fimages\u002Fdogs.webp",{"title":402,"searchDepth":403,"depth":403,"links":404},"",2,[405,406,407,408],{"id":109,"depth":403,"text":110},{"id":151,"depth":403,"text":152},{"id":297,"depth":403,"text":298},{"id":352,"depth":403,"text":353},"I am a scientist and product-focused engineering leader with over two\ndecades of experience architecting, building, and operating reliable software\nsystems for research, healthcare, and business -- in large companies\n(IBM, Genentech), zero-to-one\nstartups (Invitae, MyOme), and\nopen source collaborations (biocommons.org,\nGA4GH).  I have been a CTO, a founder and executive\ndirector of academic\u002Findustry collaboration, and I have primary and senior\nauthorship of international standards for representing biological sequence\nvariation.  I have direct experience in contract negotiation and\npartnership management.  I am currently available for full-time\nemployment or contracting in scientific software engineering or civic causes.  I\nthrive in startup environments where every day is an opportunity to create\nenduring value.","md",{},true,"\u002Fpages\u002Fabout",{"title":5,"description":409},"pages\u002Fabout","AVg93fEu-Dx-nfSHfI5EYeBTPzmILgNQvTTcGtcAkiE",1787603806823]